Epigenetics is the study of heritable changes in gene expression that are not encoded in the DNA of the genome. Encouraging evidence has linked epigenetic effects to oncogenesis, progression and treatment of cancer (1), the regulation of development and function of the nervous system (2), gene regulation (3), cellular stress events (3), nutrigenomics (4), aging and DNA repair (5). Considerable ongoing efforts are directed towards identifying the dynamic functions of various modifications to DNA and its associated proteins and elucidating their mechanisms.
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If all cells are created from the same genetic material, why are there so many different cell types? Listen to Sriharsa Pradhan, Senior Scientist, RNA Biology at NEB, as he describes how DNA is methylated and how this affects the path of reading the DNA code the same way an obstruction would derail a train off its tracks.
Watch an interactive tutorial explaining the different molecular mechanisms by which epigenetic change influences gene expression. Learn about how NEB’s reagents are targeted to the various enzymes and DNA elements that are altered by epigenetic change.
Chromatin conformation capture (3C) techniques allow study of the spatial organization of eukaryotic chromosomes in a 3D context.