Enzymes For Innovation

The NEB catalog highlights a wide variety of enzyme functionalities found in nature or engineered for specific purposes. However, in molecular biology, new tools can often lead to new discoveries. Taking advantage of the enzymology expertise at NEB, we are offering novel enzymes with interesting and unique activities for manipulating DNA, RNA, proteins and glycans, even if specific applications for them have yet to be discovered. Our hope is that by engaging researcher’s imaginations, our “Enzymes for Innovation” initiative will enable the development of new molecular techniques that so often lead to new discoveries.

Products Available

NAME	NEB#	ACTIVITY
5-hydroxymethyluridine DNA Kinase	M0659	5-hydroxymethyluridine DNA Kinase (5-HMUDK) transfers the gamma phosphate from ATP to the hydroxymethyl moiety of 5-hydroxymethyluridine in polymeric DNA.
EcoGII Methyltransferase	M0603	EcoGII Methyltransferase is a non-specific methyltransferase that modifies adenine residues (N6) in any sequence context.
Endoglycoceramidase I (EGCase I)	P0773	Catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in various glycosphingolipids.
Nb.BssSI	R0681	Generates a nick in the 3´ strand at the following recognition site: CACGAG (none/-1).
RtcB Ligase	M0458	Joins single-stranded RNA with a 3´-phosphate or 2´,3´-cyclic phosphate to another RNA with a 5´ -hydroxyl.
TelN Protelomerase	M0651	Cuts dsDNA at a TelN recognition sequence (56 bp) and leaves covalently closed ends at the site of cleavage.
Thermostable FEN1	M0645	Catalyzes the cleavage of 5´ DNA flaps from branched double-stranded DNA substrates.
Tte UvrD Helicase	M1202	Tte UvrD Helicase is a repair helicase capable of unwinding double-stranded DNA, without a requirement for a specific flap or overhang structure, from the thermophilic organism Thermoanaerobacter tengcongensis.